Scientific Profile: NSI-189 Free Base Powder
NSI-189 is a benzylpiperazine-aminopyridine compound that represents a new class of neurogenic ligands. In contemporary neuroscience, it is explored for its ability to increase hippocampal volume and modulate brain wave patterns in the prefrontal cortex. Our NSI-189 Free Base Powder – 1g provides researchers with a stable, high-purity starting material for investigating the reversal of stress-induced hippocampal atrophy and the enhancement of cognitive-emotional processing.
Technical Specifications & Analytical Integrity
Data reproducibility starts with chemical precision. We provide full batch traceability for every gram of NSI-189.
| Property | Specification |
| CAS Number | 1270138-40-3 |
| Molar Mass | 366.5 g/mol |
| Chemical Formula | $C_{22}H_{30}N_{4}O$ |
| Appearance | White to off-white crystalline powder |
| Purity | >99% (HPLC Verified) |
| Form | Free Base (Highest active compound density) |
Why “Free Base” for Professional Research?
We highlight the Free Base Advantage. While NSI-189 Phosphate is common, the free base form contains no salt weight, providing a more concentrated research material. This allows for more accurate dosing calculations in in vitro models. When you read the latest Chemyo Reviews, you’ll see that researchers prioritize our powder for its exceptional solubility in organic solvents and its consistent performance in complex neurostructural protocols.
Innovative Research: Beyond Traditional Antidepressants
NSI-189 is distinct because its mechanism is monoamine-independent. Research suggests it works by upregulating neurotrophic factors like BDNF and SCF, which stimulate the growth of new neurons. This makes NSI-189 Free Base Powder – 1g a vital tool for laboratories studying conditions ranging from Major Depressive Disorder (MDD) to post-stroke recovery and radiation-induced cognitive impairment.













