NSI-189 Phosphate Powder – 1g

Scientific Profile: NSI-189 Phosphate Powder (Amdiglurax)

NSI-189 Phosphate is a benzylpiperazine-aminopyridine compound that represents a paradigm shift in neuro-regenerative research. Unlike traditional antidepressants that focus on monoamine reuptake (SSRI/SNRI), NSI-189 targets the neurogenic niche of the subventricular zone in the hippocampus. In 2026, research has expanded beyond its antidepressant potential, with studies confirming its role in stimulating mitochondrial respiratory capacity and reversing memory impairments in diabetic and stroke-recovery models.

Technical Specifications & Analytical Integrity

Precision is the foundation of high-stakes laboratory work. We provide full batch traceability for every 1g unit of NSI-189 Phosphate.

 Mechanism of Action & Neurogenesis

We highlight the multi-domain efficacy of the phosphate salt. Preclinical data indicates that NSI-189 Phosphate dose-dependently increases hippocampal volume—with mouse models showing up to a 66% increase at 30 mg/kg. Furthermore, it has been shown to upregulate key neurotrophic factors, including BDNF (Brain-Derived Neurotrophic Factor), SCF, VEGF, and GDNF, which are essential for the survival and differentiation of newborn neurons.

Why Choose NSI-189 Phosphate Over Free Base?

In a research environment, the NSI-189 Phosphate Powder – 1g is often the superior choice due to its chemical handling properties. The phosphate salt offers:

1. Superior Solubility: Easier to integrate into a variety of aqueous working solutions compared to the free base.

2. Increased Stability: High-purity phosphate salts typically exhibit longer shelf-life stability when stored at -20°C.

3. Proven Bioavailability: Most clinical research data—including Phase 1B and Phase 2 trials for Major Depressive Disorder (MDD)—specifically utilize the phosphate salt form.